Development of Novel Furanocoumarin Dimers as Potent and Selective Inhibitors of CYP 3 A
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Development of novel furanocoumarin dimers as potent and selective inhibitors of CYP3A4.
Grapefruit juice has been found to cause an increase in the oral bioavailability of many therapeutic agents. Such interactions are believed to result from the mechanism-based inhibition of CYP3A4 activity in the intestine. Furanocoumarin dimers present in the juice have been found to be extremely potent inhibitors of CYP3A4 activity. The aim of this work was to synthesize and test a series of d...
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